[4] San Lorenzo 1-2 Rosario Central [3] 2021-05-13 00:30
Stadium: Estadio Pedro Bidegain Round: 4
Referee: Bruno Arleu de Araujo Home Manager: Diego Dabove Away Manager: Kily Gonzalez
Head to Head
| Copa Sudamericana | 2021/04/29 00:30 | Rosario Central v San Lorenzo | L | 2-0 |
| Argentina - Copa de la Liga Profesional | 2021/04/02 22:00 | San Lorenzo v Rosario Central | W | 2-0 |
| Argentina - Superliga | 2019/08/17 20:45 | San Lorenzo v Rosario Central | D | 2-2 |
| Argentina - Superliga | 2019/03/17 18:30 | Rosario Central v San Lorenzo | W | 0-1 |
| Argentina - Superliga | 2017/09/10 19:05 | Rosario Central v San Lorenzo | D | 0-0 |
| Argentina - Superliga | 2017/05/07 21:15 | San Lorenzo v Rosario Central | W | 2-1 |
| Argentina - Liga Profesional | 2016/04/17 18:30 | San Lorenzo v Rosario Central | W | 2-1 |
| Argentina - Liga Profesional | 2015/10/03 21:10 | San Lorenzo v Rosario Central | D | 2-2 |
Home History
| Argentina - Copa de la Liga Profesional | 2021/05/09 17:30 | Racing Club v San Lorenzo | L | 2-0 |
| Copa Sudamericana | 2021/05/07 00:30 | San Lorenzo v 12 de Octubre | D | 1-1 |
| Argentina - Copa de la Liga Profesional | 2021/05/02 17:20 | San Lorenzo v Godoy Cruz | W | 1-0 |
| Copa Sudamericana | 2021/04/29 00:30 | Rosario Central v San Lorenzo | L | 2-0 |
| Argentina - Copa de la Liga Profesional | 2021/04/25 21:00 | River Plate v San Lorenzo | W | 1-2 |
| Copa Sudamericana | 2021/04/21 22:15 | San Lorenzo v Huachipato | L | 0-1 |
| Argentina - Copa de la Liga Profesional | 2021/04/17 18:45 | San Lorenzo v Argentinos Jrs | D | 1-1 |
| Copa Libertadores - Kval | 2021/04/14 00:30 | Santos v San Lorenzo | D | 2-2 |
Away History
| Argentina - Copa de la Liga Profesional | 2021/05/09 17:30 | Platense v Rosario Central | L | 4-1 |
| Copa Sudamericana | 2021/05/05 22:15 | Huachipato v Rosario Central | D | 1-1 |
| Argentina - Copa de la Liga Profesional | 2021/05/03 00:00 | Rosario Central v Newell's | W | 3-0 |
| Copa Sudamericana | 2021/04/29 00:30 | Rosario Central v San Lorenzo | W | 2-0 |
| Argentina - Copa de la Liga Profesional | 2021/04/26 00:00 | Rosario Central v Estudiantes LP | L | 0-1 |
| Copa Sudamericana | 2021/04/21 00:30 | 12 de Octubre v Rosario Central | L | 1-0 |
| Argentina - Copa de la Liga Profesional | 2021/04/16 20:15 | CA Aldosivi v Rosario Central | W | 0-1 |
| Argentina - Copa de la Liga Profesional | 2021/04/11 19:15 | Rosario Central v Banfield | W | 3-1 |