[2] Zenit St Petersburg 7-1 Spartak Moskva [7] 2021-10-24 16:00
Stadium: Gazprom Arena Round: 12
Referee: Sergei Sergeyevich Ivanov Home Manager: Sergey Semak Away Manager: Rui Vitoria
Head to Head
| Russland - Premier League | 2020/12/16 17:00 | Zenit St Petersburg v Spartak Moskva | W | 3-1 |
| Russland - Premier League | 2020/10/03 16:00 | Spartak Moskva v Zenit St Petersburg | D | 1-1 |
| Russland - Cup | 2020/07/19 15:30 | Zenit St Petersburg v Spartak Moskva | W | 2-1 |
| Russland - Premier League | 2019/12/01 16:00 | Zenit St Petersburg v Spartak Moskva | W | 1-0 |
| Russland - Premier League | 2019/09/01 16:00 | Spartak Moskva v Zenit St Petersburg | W | 0-1 |
| Russland - Premier League | 2019/03/17 16:00 | Spartak Moskva v Zenit St Petersburg | D | 1-1 |
| Europa - Vennskapskamper | 2019/01/25 15:30 | Zenit St Petersburg v Spartak Moskva | L | 0-3 |
| Russland - Premier League | 2018/09/02 16:00 | Zenit St Petersburg v Spartak Moskva | D | 0-0 |
Home History
| UEFA Champions League | 2021/10/20 19:00 | Zenit St Petersburg v Juventus | L | 0-1 |
| Russland - Premier League | 2021/10/16 11:00 | Arsenal Tula v Zenit St Petersburg | L | 2-1 |
| Russland - Premier League | 2021/10/03 13:30 | Zenit St Petersburg v PFC Sochi | L | 1-2 |
| UEFA Champions League | 2021/09/29 16:45 | Zenit St Petersburg v Malmö FF | W | 4-0 |
| Russland - Premier League | 2021/09/25 13:30 | Zenit St Petersburg v Krylia Sovetov | W | 2-1 |
| Russland - Premier League | 2021/09/20 15:30 | Rubin Kazan v Zenit St Petersburg | W | 1-3 |
| UEFA Champions League | 2021/09/14 19:00 | Chelsea v Zenit St Petersburg | L | 1-0 |
| Russland - Premier League | 2021/09/11 13:30 | Zenit St Petersburg v FC Akhmat Grozny | W | 3-1 |
Away History
| UEFA Europa League | 2021/10/20 14:30 | Spartak Moskva v Leicester | L | 3-4 |
| Russland - Premier League | 2021/10/16 16:00 | Spartak Moskva v Dinamo Moskva | D | 2-2 |
| Russland - Premier League | 2021/10/03 16:00 | FC Akhmat Grozny v Spartak Moskva | W | 0-1 |
| UEFA Europa League | 2021/09/30 16:45 | Napoli v Spartak Moskva | W | 2-3 |
| Russland - Premier League | 2021/09/25 16:00 | Spartak Moskva v FC Ufa | W | 2-0 |
| Russland - Premier League | 2021/09/20 16:30 | CSKA Moskva v Spartak Moskva | L | 1-0 |
| UEFA Europa League | 2021/09/15 14:30 | Spartak Moskva v Legia Warszawa | L | 0-1 |
| Russland - Premier League | 2021/09/11 16:00 | Spartak Moskva v FK Khimki | W | 3-1 |