[7] Michigan State 7-56 Ohio State [15] 2021-11-20 17:00
Stadium: Ohio Stadium Round: 1
Home Manager: Ryan Day Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2020/12/05 17:00 | Ohio State v Michigan State | L | 52-12 |
| NCAAF | 2019/10/05 23:30 | Michigan State v Ohio State | L | 10-34 |
| NCAAF | 2018/11/10 17:00 | Ohio State v Michigan State | L | 26-6 |
| NCAAF | 2017/11/11 17:00 | Michigan State v Ohio State | L | 3-48 |
| NCAAF | 2016/11/19 17:00 | Ohio State v Michigan State | L | 17-16 |
| NCAAF | 2015/11/21 20:30 | Ohio State v Michigan State | W | 14-17 |
| NCAAF | 2014/11/09 01:00 | Michigan State v Ohio State | L | 37-49 |
| NCAAF | 2012/09/29 12:00 | Michigan State v Ohio State | L | 16-17 |
Home History
| NCAAF | 2021/11/13 21:00 | Maryland v Michigan State | W | 21-40 |
| NCAAF | 2021/11/06 19:30 | Michigan State v Purdue | L | 29-40 |
| NCAAF | 2021/10/30 16:00 | Michigan v Michigan State | W | 33-37 |
| NCAAF | 2021/10/16 16:00 | Michigan State v Indiana | W | 20-15 |
| NCAAF | 2021/10/09 16:00 | Michigan State v Rutgers | W | 31-13 |
| NCAAF | 2021/10/02 23:30 | Western Kentucky v Michigan State | W | 31-48 |
| NCAAF | 2021/09/25 23:00 | Nebraska v Michigan State | W | 20-23 |
| NCAAF | 2021/09/18 16:00 | Michigan State v Miami Florida | W | 38-17 |
Away History
| NCAAF | 2021/11/13 20:30 | Purdue v Ohio State | W | 31-59 |
| NCAAF | 2021/11/06 16:00 | Ohio State v Nebraska | W | 26-17 |
| NCAAF | 2021/10/30 23:30 | Penn State v Ohio State | W | 24-33 |
| NCAAF | 2021/10/23 23:30 | Ohio State v Indiana | W | 54-7 |
| NCAAF | 2021/10/09 16:00 | Maryland v Ohio State | W | 17-66 |
| NCAAF | 2021/10/02 19:30 | Ohio State v Rutgers | W | 52-13 |
| NCAAF | 2021/09/25 23:30 | Akron v Ohio State | W | 7-59 |
| NCAAF | 2021/09/18 19:30 | Tulsa v Ohio State | W | 20-41 |