[4] Spartak Moskva 2-1 Napoli [1] 2021-11-24 15:30
Stadium: Otkritie Arena Round: 5
Referee: Clement Turpin Home Manager: Rui Vitoria Away Manager: Luciano Spalletti
Head to Head
| UEFA Europa League | 2021/09/30 16:45 | Napoli v Spartak Moskva | W | 2-3 |
Home History
| Russland - Premier League | 2021/11/20 16:00 | Krasnodar v Spartak Moskva | L | 2-1 |
| Russland - Premier League | 2021/11/07 16:00 | Spartak Moskva v Lokomotiv Moskva | D | 1-1 |
| UEFA Europa League | 2021/11/04 20:00 | Leicester v Spartak Moskva | D | 1-1 |
| Russland - Premier League | 2021/10/30 13:30 | Spartak Moskva v Rostov | D | 1-1 |
| Russland - Premier League | 2021/10/24 16:00 | Zenit St Petersburg v Spartak Moskva | L | 7-1 |
| UEFA Europa League | 2021/10/20 14:30 | Spartak Moskva v Leicester | L | 3-4 |
| Russland - Premier League | 2021/10/16 16:00 | Spartak Moskva v Dinamo Moskva | D | 2-2 |
| Russland - Premier League | 2021/10/03 16:00 | FC Akhmat Grozny v Spartak Moskva | W | 0-1 |
Away History
| Italia - Serie A | 2021/11/21 17:00 | Inter Milan v Napoli | L | 3-2 |
| Italia - Serie A | 2021/11/07 17:00 | Napoli v Verona | D | 1-1 |
| UEFA Europa League | 2021/11/04 17:45 | Legia Warszawa v Napoli | W | 1-4 |
| Italia - Serie A | 2021/10/31 17:00 | Salernitana v Napoli | W | 0-1 |
| Italia - Serie A | 2021/10/28 18:45 | Napoli v Bologna | W | 3-0 |
| Italia - Serie A | 2021/10/24 16:00 | Roma v Napoli | D | 0-0 |
| UEFA Europa League | 2021/10/21 19:00 | Napoli v Legia Warszawa | W | 3-0 |
| Italia - Serie A | 2021/10/17 16:00 | Napoli v Torino | W | 1-0 |