Stadium: G.B. Hodge Center
Home Manager: Dave Dickerson Away Manager: LeVelle Moton
| NCAAB | 2021/11/30 00:00 | North Carolina Central v Gardner Webb | L | 58-83 |
| NCAAB | 2021/11/27 20:00 | North Carolina Central v The Apprentice | W | 96-56 |
| NCAAB | 2021/11/24 00:00 | North Carolina Central v Warren Wilson | W | 110-32 |
| NCAAB | 2021/11/21 01:00 | North Carolina Central v Alabama State | L | 74-80 |
| NCAAB | 2021/11/17 02:00 | North Carolina Central v Iowa | L | 69-86 |
| NCAAB | 2021/11/14 00:00 | North Carolina Central v Memphis | L | 51-90 |
| NCAAB | 2021/11/10 00:00 | North Carolina Central v Richmond | L | 60-70 |
| NCAAB | 2021/03/12 02:00 | North Carolina Central v Norfolk State | L | 58-87 |
| NCAAB | 2021/11/27 21:00 | Furman v USC Upstate | L | 87-77 |
| NCAAB | 2021/11/24 00:00 | USC Upstate v South Carolina State | W | 82-78 |
| NCAAB | 2021/11/19 00:00 | USC Upstate v East Tenn St | L | 43-56 |
| NCAAB | 2021/11/15 23:00 | USC Upstate v St. Andrew's | W | 96-43 |
| NCAAB | 2021/11/13 00:00 | USC Upstate v Charlotte U | L | 64-76 |
| NCAAB | 2021/11/10 00:00 | USC Upstate v SC Gamecocks | L | 60-78 |
| NCAAB | 2021/02/27 21:00 | USC Upstate v High Point | L | 60-65 |
| NCAAB | 2021/02/22 23:00 | Gardner Webb v USC Upstate | L | 69-58 |