[15] BUF Sabres 3-5 STL Blues [2] 2022-02-26 01:00
Stadium: Enterprise Center
Home Manager: Craig Berube Away Manager: Don Granato
Head to Head
| NHL | 2020/01/10 01:00 | BUF Sabres v STL Blues | L | 1-5 |
| NHL | 2019/12/11 00:30 | STL Blues v BUF Sabres | W | 2-5 |
| NHL | 2019/03/17 21:00 | STL Blues v BUF Sabres | W | 3-4 |
| NHL | 2018/12/28 01:00 | BUF Sabres v STL Blues | L | 1-4 |
| NHL | 2018/02/04 00:00 | STL Blues v BUF Sabres | L | 1-0 |
| NHL | 2017/12/11 00:00 | BUF Sabres v STL Blues | L | 2-3 |
| NHL | 2017/02/18 18:00 | STL Blues v BUF Sabres | W | 2-3 |
| NHL | 2016/11/16 01:00 | BUF Sabres v STL Blues | L | 1-4 |
Home History
| NHL | 2022/02/24 00:30 | BUF Sabres v MON Canadiens | L | 0-4 |
| NHL | 2022/02/20 23:00 | BUF Sabres v CLB Blue Jackets | L | 3-7 |
| NHL | 2022/02/19 18:00 | COL Avalanche v BUF Sabres | L | 5-3 |
| NHL | 2022/02/18 00:00 | OTT Senators v BUF Sabres | L | 3-1 |
| NHL | 2022/02/16 00:00 | NY Islanders v BUF Sabres | W | 3-6 |
| NHL | 2022/02/13 17:30 | BUF Sabres v MON Canadiens | W | 5-3 |
| NHL | 2022/02/11 00:00 | CLB Blue Jackets v BUF Sabres | L | 4-3 |
| NHL | 2022/02/02 03:00 | BUF Sabres v VGS Golden Knights | L | 2-5 |
Away History
| NHL | 2022/02/23 00:00 | STL Blues v PHI Flyers | W | 4-1 |
| NHL | 2022/02/20 00:00 | STL Blues v TOR Maple Leafs | W | 6-3 |
| NHL | 2022/02/18 00:00 | STL Blues v MON Canadiens | L | 2-3 |
| NHL | 2022/02/16 00:00 | STL Blues v OTT Senators | W | 5-2 |
| NHL | 2022/02/13 01:00 | CHI Blackhawks v STL Blues | W | 1-5 |
| NHL | 2022/02/11 01:00 | NJ Devils v STL Blues | L | 7-4 |
| NHL | 2022/01/29 20:00 | WIN Jets v STL Blues | L | 4-1 |
| NHL | 2022/01/28 01:00 | CAL Flames v STL Blues | W | 1-5 |