| ITF W60 Las Vegas | 11/06 20:05 | 25 | [263] Jamie Loeb v Varvara Lepchenko [170] | 2-6,0-6 | |
| ITF W80 Macon | 10/23 15:30 | 25 | [387] Coco Vandeweghe v Varvara Lepchenko [135] | Retired | |
| WTA Luxembourg | 10/13 14:40 | 46 | Renata Voracova v Varvara Lepchenko | 7-5,7-6 | |
| WTA Luxembourg | 10/12 18:15 | 45 | [220] Katharina Hobgarski v Varvara Lepchenko [136] | 2-6,7-6,3-6 | |
| WTA Linz | 10/06 08:00 | 45 | [136] Varvara Lepchenko v Pauline Parmentier [123] | 6-7,4-6 | |
| ITF W60 Templeton | 09/27 01:00 | 26 | Varvara Lepchenko v Maria Mateas | 6-7,0-6 | |
| ITF W60 Templeton | 09/25 22:30 | 25 | [137] Varvara Lepchenko v Ashley Kratzer [429] | 6-0,6-2 | |
| WTA Guangzhou | 09/14 07:05 | 45 | [121] Varvara Lepchenko v Magdalena Frech [207] | Retired | |
| WTA Hiroshima | 09/09 06:45 | 25 | [118] Varvara Lepchenko v Veronika Kudermetova [51] | 4-6,2-6 | |
| WTA New Haven | 09/05 15:50 | 26 | [118] Varvara Lepchenko v Lauren Davis [73] | 6-4,0-6,4-6 | |
| WTA New Haven | 09/04 18:05 | 25 | [118] Varvara Lepchenko v Lara Arruabarrena [155] | 6-1,4-6,6-4 | |
| US Open - Kvinner | 08/26 20:05 | 23 | [167] Shuai Peng v Varvara Lepchenko [118] | 6-2,7-6 | |
| US Open - Kvinner | 08/23 19:55 | 46 | [118] Varvara Lepchenko v Timea Babos [112] | 6-7,4-6 | |
| US Open - Kvinner | 08/22 15:00 | 45 | [118] Varvara Lepchenko v Georgina G-Perez [223] | 6-4,7-6 | |
| US Open - Kvinner | 08/20 22:20 | 44 | [118] Varvara Lepchenko v Kai-Lin Zhang [219] | 4-6,6-1,6-4 | |
| ITF W100 Vancouver | 08/13 18:40 | 25 | [277] Leylah A Fernandez v Varvara Lepchenko [116] | 6-3,7-6 | |
| WTA Toronto | 08/04 14:00 | 45 | [37] Alison Riske v Varvara Lepchenko [117] | 6-4,6-4 | |
| WTA Toronto | 08/03 14:00 | 44 | [274] Lucie Hradecka v Varvara Lepchenko [117] | 3-6,4-6 | |
| WTA Bucuresti | 07/16 16:00 | 25 | [117] Varvara Lepchenko v Martina Di Giuseppe [211] | 6-3,1-6,6-7 | |
| ITF W100 Contrexeville | 07/11 09:30 | 26 | [124] Varvara Lepchenko v Tessah Andrianjafitrimo [334] | 6-1,1-6,0-6 | |
| ITF W100 Contrexeville | 07/09 11:05 | 25 | [124] Varvara Lepchenko v Quirine Lemoine [244] | 6-2,6-7,6-4 | |
| Wimbledon - Kvinner | 06/26 14:35 | 45 | [123] Varvara Lepchenko v Lesley Kerkhove [203] | 6-4,1-6,2-6 | |
| Wimbledon - Kvinner | 06/25 13:40 | 44 | [123] Varvara Lepchenko v Sofya Zhuk [158] | 7-6,2-6,6-0 | |
| WTA Mallorca | 06/18 09:00 | 25 | [123] Varvara Lepchenko v Anastasija Sevastova [12] | 3-6,6-7 | |
| WTA Mallorca | 06/17 10:15 | 64 | [173] Kurumi Nara v Varvara Lepchenko [123] | 4-6,6-2,0-6 | |
| WTA Mallorca | 06/16 09:30 | 45 | [165] Irina Bara v Varvara Lepchenko [127] | 6-2,1-6,2-6 | |
| WTA Hertogenbosch | 06/10 10:25 | 25 | [127] Varvara Lepchenko v Elena Rybakina [134] | 1-6,2-6 | |
| WTA Hertogenbosch | 06/09 13:10 | 64 | [129] Varvara Lepchenko v Anna Kalinskaya [146] | 6-2,7-6 | |
| WTA Hertogenbosch | 06/08 15:15 | 45 | Varvara Lepchenko v Indy De Vroome | 6-1,6-4 | |
| French Open - Kvinner | 05/27 11:35 | 23 | [50] Shuai Zhang v Varvara Lepchenko [129] | 6-1,6-1 |